Category Archives: Δημοσιευμένες εργασίες

21Mar/18

gamma-H2AX: Can it be established as a classical cancer prognostic factor?

Viktoria-Varvara Palla, Georgios Karaolanis, Ioannis Katafigiotis, Ioannis Anastasiou, Paul Patapis, Dimitrios Dimitroulis and Despoina Perrea

Abstract
Double-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to doublestrand breaks, and the gamma-H2AX is formatted as a result of genomic instability. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. gamma-H2AX has already been investigated in a variety of cancer types, including breast, lung, colon, cervix, and ovary cancers. The prognostic value of gamma-H2AX is indicated in certain cancer types, such as breast or endometrial cancer, but further investigation is needed to establish gamma-H2AX as a prognostic marker. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma-H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor.

Keywords: gamma-H2AX, cancer, prognosis, histone, DNA damage

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28Oct/16

Thyroid Function and Autoimmunity Versus Number of Pregnancies

Dimitrios Boufas1, Andromachi Vryonidou 1, Georgios Mastorakos 2, Ioannis Ilias 3

1Department of Endocrinology, Hellenic Red Cross Hospital, Athens, Greece, 2Endocrine Unit, Department of Obstetrics and Gynecology, Athens University Medical School, Aretaieion University Hospital, Athens, Greece, 3Department of Endocrinology, Elena Venizelou Hospital, Athens, Greece
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