Category Archives: Δημοσιευμένες εργασίες

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The effects of autoimmune disorders on mental health of women in reproductive age.

Hell Iatr 2018; 84: 15-22.

Salioni A-M, Christopoulos P, Zervas I, Mastorakos G.

Nowadays, we know how important is to understand being healthy. Contrary to this, we have to investigate more and more the hidden faces of longterm illnesses and find the reasons of morbidity. The activation of autoimmunity inclines to be increased in contemporary time, not only in Greece, but also globally, without understanding the causes. The systematic erythematosus lupus (SEL) and rheumatoid arthritis (RA) are, probably, two of the most characteristic examples of up to date chronic autoimmunity diseases. Women are more frequent affected than men in proportion of 3:1, a fact that create changes not only physical and organic, but also psychological. Additionally, there are a lot of chances either in childhood or in reproductive and old one. The psychological morbidity is taking place in most of these diseases, affecting the patients’ behavior and their position against them. Multiple factors are incriminated for their appearance, as fatigue, stress, anxiety, etc. In addition a lot of causes affect their development both at their remission and at their relapse. The depression dominate and is promptly correlated both with the systematic erythematosus lupus and rheumatoid arthritis.

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Increased risk of non-alcoholic fatty liver disease in women with gestational diabetes mellitus: A population-based cohort study, systematic review and meta-analysis.

J Diabetes Complications. 2019 Jun 27. pii: S1056-8727(19)30092-3. doi: 10.1016/j.jdiacomp.2019.06.006. [Epub ahead of print]

Lavrentaki A, Thomas T, Subramanian A, Valsamakis G, Thomas N, Toulis KA, Wang J, Daly B, Saravanan P, Sumilo D, Mastorakos G, Tahrani AA, Nirantharakumar K.

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gamma-H2AX: Can it be established as a classical cancer prognostic factor?

Viktoria-Varvara Palla, Georgios Karaolanis, Ioannis Katafigiotis, Ioannis Anastasiou, Paul Patapis, Dimitrios Dimitroulis and Despoina Perrea

Abstract
Double-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to doublestrand breaks, and the gamma-H2AX is formatted as a result of genomic instability. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. gamma-H2AX has already been investigated in a variety of cancer types, including breast, lung, colon, cervix, and ovary cancers. The prognostic value of gamma-H2AX is indicated in certain cancer types, such as breast or endometrial cancer, but further investigation is needed to establish gamma-H2AX as a prognostic marker. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma-H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor.

Keywords: gamma-H2AX, cancer, prognosis, histone, DNA damage

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