{"id":1653,"date":"2016-10-30T09:17:41","date_gmt":"2016-10-30T09:17:41","guid":{"rendered":"http:\/\/researchreproduction.gr\/site\/?p=1653"},"modified":"2016-10-30T09:31:07","modified_gmt":"2016-10-30T09:31:07","slug":"prediction-of-pre-eclampsia-combining-ngal-and-other-biochemical-markers-with-doppler-in-the-first-andor-second-trimester-of-pregnancy-a-pilot-study","status":"publish","type":"post","link":"https:\/\/researchreproduction.gr\/site\/?p=1653","title":{"rendered":"Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and\/or second trimester of pregnancy. A pilot study."},"content":{"rendered":"<p>Grigorios A. Karampas <sup>a,1,<\/sup>*, Makarios I. Eleftheriades <sup>a,b<\/sup>, Konstantinos C. Panoulis <sup>a<\/sup>, Myrto D. Rizou <sup>c<\/sup>, Alexander D. Haliassos <sup>c<\/sup>, Dimitra K. Metallinou <sup>d<\/sup>, George P. Mastorakos <sup>e<\/sup>, Demetrios A. Rizos <sup>a,f<\/sup><br \/>\n<!--more--><br \/>\n<sup>a<\/sup> Second Department of Obstetrics &amp; Gynecology, Medical School, University of Athens \u2018\u2018Aretaieio\u2019\u2019 Hospital, Athens, Greece<br \/>\n<sup>b<\/sup> \u2018\u2018EmbryoCare\u2019\u2019, Fetal Medicine Unit, Athens, Greece<br \/>\n<sup>c<\/sup> \u2018\u2018Diamedica SA\u2019\u2019, Clinical Chemistry Laboratory, Athens, Greece<br \/>\n<sup>d<\/sup> Department of Midwifery, Faculty of Health and Caring Professions, Technological Educational Institute of Athens, Athens, Greece<br \/>\n<sup>e<\/sup> Endocrine Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, University of Athens, Athens, Greece<br \/>\n<sup>f<\/sup> Hormone Laboratory, \u2018\u2018Aretaieio\u2019\u2019 Hospital, Athens, Greece<\/p>\n<p><strong>Abstract<\/strong><br \/>\nObjective: To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks\u2019 gestation. Study design: Prospectively enrolled women at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein \u2013 A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1\/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9\/NGAL complex were recorded. Results: Combination of NGAL and BMI in a logistic regression model detected 70% of PE in the first trimester (p = 0.001). Including UtA-PI and DV-PI in the model sensitivity reached 77.8% with 96.6% specificity (p = 0.004). Combination of second trimester NGAL and s-Flt-1\/PLGF ratio yield specificity 100% (p = 0.001). Combination of second trimester UtA-PI with first trimester NGAL, BMI and age detected 80% of PE with specificity 91.9% (p = 0.001). Conclusion: Combination of NGAL, maternal characteristics and Doppler parameters in the first and\/or second trimester can detect a consistent number of PE pregnancies. NGAL is a potent new biomarker for the prediction of preeclampsia.<\/p>\n<p><a href=\"https:\/\/researchreproduction.gr\/site\/wp-content\/uploads\/2016\/10\/1-s2.0-S030121151630882X-main.pdf\" target=\"_blank\">Read Full Article (PDF)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Grigorios A. Karampas a,1,*, Makarios I. Eleftheriades a,b, Konstantinos C. Panoulis a, Myrto D. Rizou c, Alexander D. Haliassos c, Dimitra K. Metallinou d, George P. Mastorakos e, Demetrios A. Rizos a,f<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1653","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/1653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1653"}],"version-history":[{"count":2,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/1653\/revisions"}],"predecessor-version":[{"id":1657,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/1653\/revisions\/1657"}],"wp:attachment":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}