{"id":1658,"date":"2016-10-30T09:37:17","date_gmt":"2016-10-30T09:37:17","guid":{"rendered":"http:\/\/researchreproduction.gr\/site\/?p=1658"},"modified":"2016-10-30T09:37:17","modified_gmt":"2016-10-30T09:37:17","slug":"changes-of-serum-sclerostin-and-dickkopf-1-levels-during-the-menstrual-cycle-a-pilot-study","status":"publish","type":"post","link":"https:\/\/researchreproduction.gr\/site\/?p=1658","title":{"rendered":"Changes of serum sclerostin and Dickkopf-1 levels during the menstrual cycle. A pilot study"},"content":{"rendered":"

Chrysoula G. Liakou1<\/sup>, George Mastorakos2<\/sup>, Konstantinos Makris3<\/sup>, Ioannis G. Fatouros4<\/sup>, Alexandra Avloniti5<\/sup>, Helen Marketos3<\/sup>, Julia D. Antoniou1<\/sup>, Antonios Galanos1<\/sup>, Ismene Dontas1<\/sup>, Demetrios Rizos6<\/sup>, Symeon Tournis1<\/sup>
\n
\n1<\/sup> Laboratory for Research of the Musculoskeletal System \u201cTh. Garofalidis\u201d, Medical School, Athens University, KAT Hospital, 10 Athinas Str., Kifissia, 14561 Athens, Greece
\n2<\/sup> Unit of Endocrinology, Diabetes and Metabolism, Aretaieion Hospital, Athens Medical School, Athens University, 76 Vas. Sofias Av., 11528 Athens, Greece
\n3<\/sup> Department of Biochemistry, KAT Hospital, 10 Athinas Str., Kifissia, 14561 Athens, Greece
\n4<\/sup> School of Physical Education and Sports Sciences, University of Thessaly, 42100 Karies, Trikala, Greece
\n5<\/sup> School of Physical Education and Sports Sciences, Democritus University of Thrace, 69100 Komotini, Greece
\n6<\/sup> Hormone Laboratory, Aretaieion Hospital, Medical School, Athens University, 76 Vas. Sofias Av., 11528 Athens, Greece<\/p>\n

Abstract <\/strong>
\nStudies in postmenopausal women have identified sclerostin as a strong candidate for mediating estrogen effects on the skeleton. The effects of estradiol on sclerostin and Dickkopf-1 in younger women remain unclear. The main purpose of this study is to investigate the impact of estradiol and gonadotrophins fluctuations during the menstrual cycle on circulating sclerostin and Dickkopf-1 levels and the possible relationship of sclerostin and Dickkopf-1 with changes in N-terminal propeptide of type 1 collagen and C-telopeptide of collagen cross-links. Fourteen healthy premenopausal Caucasian women, with regular menses, aged 33.6 \u00b1 4.5 years participated. After the first day of menstruation and every-other-day up to the next menses, fasting serum estradiol, luteinizing hormone, folliclestimulating hormone, sclerostin, Dickkopf-1, N-terminal propeptide of type 1 collagen, and C-telopeptide of collagen cross-links levels were measured in peripheral blood. Participants completed dietary questionnaires and the International physical activity questionnaire during the cycle. Neither sclerostin nor Dickkopf-1 levels changed significantly across the menstrual cycle (p = 0.18 and p = 0.39, respectively), while N-terminal propeptide of type 1 collagen and C-telopeptide of collagen cross-links levels presented cyclic variation (p < 0.001 and p = 0.004, respectively). Baseline sclerostin (29.23 \u00b1 10.62 pmol\/L) positively correlated with N-terminal propeptide of type 1 collagen (r = 0.71, p < 0.01) and C-telopeptide of collagen cross-links (r = 0.63, p < 0.05), while Dickkopf-1 (4.82 \u00b1 2.23 pmol\/L) correlated positively with N-terminal propeptide of type 1 collagen (r = 0.56, p < 0.05). Mid-cycle E2 levels presented significant negative association with the percent decrease of C-telopeptide of collagen cross-links at all-time points during the luteal period (r = \u22120.60 to \u22120.68, p < 0.05\u20130.01). Circulating sclerostin and Dickkopf-1 levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women. Further investigation is needed concerning the role of sclerostin and Dickkopf-1 on bone turnover in young estrogen-sufficient women.<\/p>\n

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Chrysoula G. Liakou1, George Mastorakos2, Konstantinos Makris3, Ioannis G. Fatouros4, Alexandra Avloniti5, Helen Marketos3, Julia D. Antoniou1, Antonios Galanos1, Ismene Dontas1, Demetrios Rizos6, Symeon Tournis1<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1658","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/1658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1658"}],"version-history":[{"count":1,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/1658\/revisions"}],"predecessor-version":[{"id":1660,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/1658\/revisions\/1660"}],"wp:attachment":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}