{"id":1661,"date":"2016-10-30T09:57:59","date_gmt":"2016-10-30T09:57:59","guid":{"rendered":"http:\/\/researchreproduction.gr\/site\/?p=1661"},"modified":"2016-10-30T10:02:14","modified_gmt":"2016-10-30T10:02:14","slug":"dysregulation-of-11beta-hydroxysteroid-dehydrogenases-implications-during-pregnancy-and-beyond","status":"publish","type":"post","link":"https:\/\/researchreproduction.gr\/site\/?p=1661","title":{"rendered":"Dysregulation of 11beta-hydroxysteroid dehydrogenases: implications during pregnancy and beyond."},"content":{"rendered":"<p>Konstantakou P<sup>1<\/sup>, Mastorakos G<sup>1<\/sup>, Vrachnis N<sup>2<\/sup>, Tomlinson JW<sup>3<\/sup>, Valsamakis G<sup>1<\/sup><br \/>\n<!--more--><\/p>\n<p><sup>1<\/sup>a Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieio Hospital , Athens , Greece .<br \/>\n<sup>2<\/sup>b Department of Obstetrics and Gynecology , Aretaieio Hospital , Athens , Greece .<br \/>\n<sup>3<<\/sup>c Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital , Headington , UK.<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Glucococorticoids play a critical role in the developmental programing and fetal growth. Key molecules mediating and regulating tissue-specific glucocorticoid actions are 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 and 2 isozymes, both of which are expressed in the placenta and the fetal membranes. 11beta-HSD1 is implicated in the pathogenesis of metabolic syndrome and its dysregulation has been observed in pregnancy-related complications (pre-eclampsia, intrauterine growth restriction). Interestingly, preliminary clinical data have associated certain 11beta-HSD1 gene polymorphisms with hypertensive disorders in pregnancy, suggesting, if confirmed by further targeted studies, it&#8217;s potential as a putative prognostic marker. Animal studies and observations in humans have confirmed that 11beta-HSD2 insufficiency is related with pregnancy adversity (pre-eclampsia, intrauterine growth restriction, preterm birth). Importantly, down-regulation or deficiency of placental 11beta-HSD2 is associated with significant restriction in fetal growth and low-birth weight, and unfavorable cardio-metabolic profile in adulthood. The potential association of 11beta-HSD1 tissue-specific dysregulation with gestational diabetes, as well as the plausible utility of 11beta-HSD2, as a biomarker of pregnancy adversity and later life morbidity, are emerging areas of intense scientific interest and future investigation.<\/p>\n<p><a href=\"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/14767058.2016.1171308\" target=\"_blank\">Read Article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Konstantakou P1, Mastorakos G1, Vrachnis N2, Tomlinson JW3, Valsamakis G1<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1661","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/1661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1661"}],"version-history":[{"count":2,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/1661\/revisions"}],"predecessor-version":[{"id":1663,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/1661\/revisions\/1663"}],"wp:attachment":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}