{"id":2165,"date":"2018-03-21T09:54:13","date_gmt":"2018-03-21T09:54:13","guid":{"rendered":"http:\/\/researchreproduction.gr\/site\/?p=2165"},"modified":"2018-08-10T17:45:45","modified_gmt":"2018-08-10T17:45:45","slug":"gamma-h2ax-can-it-be-established-as-a-classical-cancer-prognostic-factor","status":"publish","type":"post","link":"https:\/\/researchreproduction.gr\/site\/?p=2165","title":{"rendered":"gamma-H2AX: Can it be established as a classical cancer prognostic factor?"},"content":{"rendered":"<p>[:EL]Viktoria-Varvara Palla, Georgios Karaolanis, Ioannis Katafigiotis, Ioannis Anastasiou, Paul Patapis, Dimitrios Dimitroulis and Despoina Perrea<\/p>\n<p><!--more--><\/p>\n<p>Abstract<br \/>\nDouble-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to doublestrand breaks, and the gamma-H2AX is formatted as a result of genomic instability. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. gamma-H2AX has already been investigated in a variety of cancer types, including breast, lung, colon, cervix, and ovary cancers. The prognostic value of gamma-H2AX is indicated in certain cancer types, such as breast or endometrial cancer, but further investigation is needed to establish gamma-H2AX as a prognostic marker. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma-H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor.<\/p>\n<p>Keywords: gamma-H2AX, cancer, prognosis, histone, DNA damage<\/p>\n<p><a href=\"https:\/\/researchreproduction.gr\/site\/wp-content\/uploads\/2018\/03\/Palla.pdf\" target=\"_blank\" rel=\"noopener\">Download PDF<\/a>[:en]Viktoria-Varvara Palla, Georgios Karaolanis, Ioannis Katafigiotis, Ioannis Anastasiou, Paul Patapis, Dimitrios Dimitroulis and Despoina Perrea<\/p>\n<p>Abstract<br \/>\nDouble-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to doublestrand breaks, and the gamma-H2AX is formatted as a result of genomic instability. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. gamma-H2AX has already been investigated in a variety of cancer types, including breast, lung, colon, cervix, and ovary cancers. The prognostic value of gamma-H2AX is indicated in certain cancer types, such as breast or endometrial cancer, but further investigation is needed to establish gamma-H2AX as a prognostic marker. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma-H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor.<\/p>\n<p>Keywords: gamma-H2AX, cancer, prognosis, histone, DNA damage<\/p>\n<p><a href=\"https:\/\/researchreproduction.gr\/site\/wp-content\/uploads\/2018\/03\/Palla.pdf\" target=\"_blank\" rel=\"noopener\">Download PDF<\/a>[:]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[:EL]Viktoria-Varvara Palla, Georgios Karaolanis, Ioannis Katafigiotis, Ioannis Anastasiou, Paul Patapis, Dimitrios Dimitroulis and Despoina Perrea<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2165","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/2165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2165"}],"version-history":[{"count":4,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/2165\/revisions"}],"predecessor-version":[{"id":2244,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/2165\/revisions\/2244"}],"wp:attachment":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}