S. Spanou – D. Kalogiannis – E. Zapanti – M. Gazouli – I. A. Sfontouris\u00a0 – C. Siristatidis – George Mastorakos<\/p>\n
Abstract<\/strong><\/p>\n Purpose<\/em> To calculate the concentrations of interleukin 15 (IL-15) in follicular fluid (FF) and evaluate their relation with oocyte maturation, follicle size, and patients\u2019 body mass index (BMI) and age. S. Spanou – D. Kalogiannis – E. Zapanti – M. Gazouli – I. A. Sfontouris\u00a0 – C. Siristatidis – George Mastorakos Abstract Purpose To calculate the concentrations of interleukin 15 (IL-15) in follicular fluid (FF) andRead More…<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2426","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/2426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2426"}],"version-history":[{"count":4,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/2426\/revisions"}],"predecessor-version":[{"id":3898,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/2426\/revisions\/3898"}],"wp:attachment":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nMethods<\/em> Follicular fluid specimens were obtained from 56 subfertile women undergoing intracytoplasmic sperm injection (ICSI) during oocyte retrieval for measurement of IL-15 concentrations with ELISA. Wilcoxon\u2019s test and Pearson\u2019s correlation coefficient were used to correlate FF concentrations of IL-15with follicular size and stage of oocytematuration, along with patients\u2019 BMI and age.
\nResults<\/em> IL-15 concentrations in FF of follicles with immature oocytes were significantly greater than those from follicles with mature ones (median 5.333 vs. 3.250 pg\/ml, respectively, p < 0.001). There was a significant negative correlation between IL-15 concentrations and follicle size (r = \u2212 0.333, p = 0.003). No significant correlation was observed between IL-15 concentrations and patients\u2019 BMI and age (p > 0.05).
\nConclusions<\/em> IL-15 concentrations in FF are adversely related with the size of the follicles and the maturity of the corresponding retrieved oocytes in a cohort of expected normal responders undergoing intracytoplasmic sperm injection (ICSI). Follicular fluid concentrations of IL-15 should be investigated as a possible predictive factor for oocyte maturity.<\/p>\n","protected":false},"excerpt":{"rendered":"