{"id":3382,"date":"2022-09-10T11:15:09","date_gmt":"2022-09-10T11:15:09","guid":{"rendered":"https:\/\/researchreproduction.gr\/site\/?p=3382"},"modified":"2023-08-24T12:40:50","modified_gmt":"2023-08-24T12:40:50","slug":"metabolic-responsiveness-to-training-depends-on-insulin-sensitivity-and-protein-content-of-exosomes-in-insulin-resistant-males","status":"publish","type":"post","link":"https:\/\/researchreproduction.gr\/site\/?p=3382","title":{"rendered":"Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males[:]"},"content":{"rendered":"

C E L L\u00a0 B I O L O G Y<\/span><\/p>\n

Maria<\/span> Apostolopoulou<\/span>, Lucia<\/span> Mastrototaro<\/span>, Sonja<\/span> Hartwig<\/span>, Dominik<\/span> Pesta<\/span>, <\/span>Klaus <\/span>Stra\u00dfburger<\/span>, Elisabetta<\/span> de<\/span> Filippo<\/span>, Tomas<\/span> Jelenik<\/span>, Yanislava<\/span> Karusheva<\/span>, <\/span>Sofiya<\/span> Gancheva<\/span>, Daniel<\/span> Markgraf<\/span>, Christian<\/span> Herder<\/span>, K.<\/span> Sreekumaran<\/span> Nair<\/span>, <\/span>Andreas S.<\/span> Reichert<\/span> , Stefan<\/span> Lehr<\/span>, Karsten<\/span> M\u00fcssig<\/span>, Hadi<\/span> Al-Hasani<\/span>, <\/span>Julia<\/span> Szendroedi<\/span> , Michael<\/span> Roden<\/span>

High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO<\/span>2<\/span>max), but its impact on metabolism <\/span>remains unclear. We hypothesized that 12-week HIIT increases insulin sensitivity in males with or without type 2 <\/span>diabetes [T2D and NDM (nondiabetic humans)]. However, despite identically higher VO<\/span>2<\/span>max, mainly insulin-resistant <\/span>(IR) persons (T2D and IR NDM) showed distinct alterations of circulating small extracellular vesicles (SEVs) along <\/span>with lower inhibitory metabolic (protein kinase C<\/span>\u03b5<\/span> activity) or inflammatory (nuclear factor<\/span> \u03ba<\/span>B) signaling in muscle <\/span>of T2D or IR NDM, respectively. This is related to the specific alterations in SEV proteome reflecting down-regulation <\/span>of the phospholipase C pathway (T2D) and up-regulated antioxidant capacity (IR NDM). Thus, SEV cargo may con-<\/span>tribute to modulating the individual metabolic responsiveness to exercise training in humans.<\/span><\/p>\n

Read Full Article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

C E L L\u00a0 B I O L O G Y Maria Apostolopoulou, Lucia Mastrototaro, Sonja Hartwig, Dominik Pesta, Klaus Stra\u00dfburger, Elisabetta de Filippo, Tomas Jelenik, Yanislava Karusheva, Sofiya Gancheva, Daniel Markgraf, Christian Herder, K. SreekumaranRead More…<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-3382","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/3382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3382"}],"version-history":[{"count":4,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/3382\/revisions"}],"predecessor-version":[{"id":3828,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/3382\/revisions\/3828"}],"wp:attachment":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}