{"id":4001,"date":"2023-09-02T12:21:55","date_gmt":"2023-09-02T12:21:55","guid":{"rendered":"https:\/\/researchreproduction.gr\/site\/?p=4001"},"modified":"2023-09-02T12:26:35","modified_gmt":"2023-09-02T12:26:35","slug":"regulation-of-lipogenesis-in-human-hepatocytes-by-androgens-glucocorticoids-and-5%ce%b1-reductase","status":"publish","type":"post","link":"https:\/\/researchreproduction.gr\/site\/?p=4001","title":{"rendered":"Regulation of lipogenesis in human hepatocytes by androgens, glucocorticoids and 5\u03b1-reductase"},"content":{"rendered":"<p>N Nikolaou, M Nasiri, LL Gathercole, S Parajes, N Krone, G Valsamakis, G Mastorakos3, JW Tomlinson<\/p>\n<p>Increased mRNA expression of FAS, ACC1 and ACC2 as well decreased CPT1 mRNA expression contribute to the increase in de novo lipogenesis that is observed<br \/>\nwith testosterone and DHT treatment. Surprisingly, we also observed that AR overexpression alone, in the absence of ligand, also regulates hepatic lipid metabolism<br \/>\nby increasing both the expression of key components of the lipogenic pathway (FAS, ACC1, ACC2) and functional lipid accumulation. We have shown that<br \/>\nglucocorticoids decrease de novo lipogenesis in a dose-dependent manner and manipulation of 5\u03b1R2 activity can regulate lipogenesis in human hepatocytes in vitro.<br \/>\nThese data demonstrate that androgens and glucocorticoids are able to stimulate lipid accumulation in human hepatocytes and this may be crucial in understanding<br \/>\nthe association between PCOS and NAFLD.<\/p>\n<p><a href=\"https:\/\/researchreproduction.gr\/site\/wp-content\/uploads\/2023\/09\/Nikolaou_ECE-2015-poster.pdf\" target=\"_blank\" rel=\"noopener\">Full Poster<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>N Nikolaou, M Nasiri, LL Gathercole, S Parajes, N Krone, G Valsamakis, G Mastorakos3, JW Tomlinson Increased mRNA expression of FAS, ACC1 and ACC2 as well decreased CPT1 mRNA expression contribute to the increase in de<a class=\"moretag\" href=\"https:\/\/researchreproduction.gr\/site\/?p=4001\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-4001","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/4001","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4001"}],"version-history":[{"count":3,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/4001\/revisions"}],"predecessor-version":[{"id":4005,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=\/wp\/v2\/posts\/4001\/revisions\/4005"}],"wp:attachment":[{"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4001"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4001"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/researchreproduction.gr\/site\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4001"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}