Νικόλαος Φ. Βλάχος

Vlachos_resizeΑποφοίτησε απο την Ιατρική Σχολή του Πανεπιστήμιου Αθηνών τον Ιούνιο του 1989 με το βαθμό « Άριστα».
Από τον Ιούλιο του 1993 μέχρι τον Ιούνιο του 1997 εξειδικεύτηκε στην Μαιευτική και Γυναικολογία στο Πανεπιστημιακό Νοσοκομείο Brookdale των Ηνωμένων Πολιτειών.
Τον Ιούλιο του 1997 μεχρι τον Ιουνιο του 2004 έγινε δεκτός στο Πανεπιστήμιο Johns Hopkins των ΗΠΑ (Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology) στην υποειδικοτητα της Αναπαραγωγικής Ενδοκρινολογιας και υποβοηθούμενης αναπαραγωγής. Τον Ιούλιο του 1999 ανακηρύχθηκε διδάκτορας του Πανεπιστημίου Johns Hopkins και προάγεται στον Ακαδημαϊκό βαθμό του Instructor (Ισοδύναμο του βαθμού Λέκτορος).


Τον Ιούλιο του 2000 προήχθει στον βαθμό του Assistant Professor (Ισοδύναμο με το βαθμό του Επίκουρου καθηγητού) στο πανεπιστήμιο Johns Hopkins στο τμήμα μαιευτικής και γυναικολογίας. με αρμοδιότητες συνδιευθυντή (Co-director) στο τμήμα εξωσωματικής γονιμοποίησης, και σαν διευθυντής του τμήματος ενδομητρίωσης και λαπαροσκοπικής χειρουργικής.
Το Σεπτεβριο του 2004 διοριζεται με το βαθμο του επικουρου καθηγητη στην Β Mαιευτική και Γυναικολογική κλινική του πανεπιστήμιου Αθηνών.

Τιμητικές διακρίσεις και βραβεία:

1995: Υποτροφία του Ιδρύματος Λίλιαν Βουδούρη ως Αριστούχος της Ιατρικής.
1997 βραβείο της Αμερικανικής Εταιρείας Λαπαροσκοπικής Χειρουργικής για εξαιρετική επίδοση στην λαπαροσκοπική χειρουργική.
1996 Chief Resident in Obstetrics and Gynecology
1996 Βραβείο Galloway (Το βραβείο απονέμεται σε πέντε ειδικευόμενους το χρόνο από όλα τα προγράμματα γυναικολογίας των Ηνωμένων Πολιτειών και περιλαμβάνει χρηματικό έπαθλο 1.500 δολαρίων και εντατική εκπαίδευση στο τμήμα Γυναικολογικής Ογκολογίας του Νοσοκομείου Memorial Sloan Kettering της Νέας Υόρκης).
1997: 1o βραβείο της Μαιευτικής και Γυναικολογικής Εταιρείας του Brooklyn New York για το ερευνητικό πρωτόκολλο ¨Συσχέτιση μεταξύ Μικρολευκωματουρίας κατά την κύηση και προεκλαμψίας
2002 Μέλος του συμβουλίου για εκπαίδευση πάνω στην χορήγηση ορμονών (Council on Hormone Education)
2002 Co-Chair στο Continuing Medical education (CME) program for Advanced Studies in Medicine
2002 πρόταση για συμμετοχή στο Who is Who in Medicine and Healthcare
2004 πρόταση για συμμετοχή στο Who is Who in America

Πτυχία και Διπλώματα:

Diplomate of the American Board of Obstetricians and Gynecologists
Diplomate of the American Society for Reproductive Medicine

Ερευνητικό έργο:

Εργαστηριακές τεχνικές: Tissue Culture Systems,
RNA and DNA extraction,
RT-PCR,
Southern and Western blots,
Immunohistochemistry methods

Εργαστηριακή έρευνα:

Prolactin Receptor expression in luteinized human granulosa cells.
Senior investigators: G. Creatsas MD, H.A. Zacur M.D., Ph.D. and J.D. Gearhart Ph.D.

Endometriosis in caloric restricted animals.
Collaboration with National Institute of Aging (part of NIH). Co- investigators: Mark H Lane PhD.

Human chorionic gonadotropin (hCG) hormone isoforms in normal and abnormal pregnancies.
Senior Investigators: E.E. Wallach, M.D., M. Shamblott, Ph.D.

Κλινική έρευνα με χρηματοδότηση:

Σαν κύριος ερευνητής:
AKZO NOBEL: Protocol # 01-01-26-06 ($75,000)
Endometrial Luteal phase characteristics and luteal phase support in controlled ovarian hyperstimulation protocols with Gonadotropin Releasing Hormone Antagonists

Συνεργάτης:

  • Warner-Lambert Co. Protocol # 376-408
    Randomized, double-blinded, active and placebo-controlled, multicenter study assessing the effect of Norethindrone Acetate (NA) and Ethinyl Estradiol (EE) on Lipids in Postmenopausal Women.
  • Organon Co. Protocol # 053-004
    Open labelled, randomised multicenter study to assess the efficacy and safety of a Follistim solution formulation compared to a Freeze-dried cake formulation, both administered subcutaneous for the induction of ovulation in clomiphene resistant subjects with chronic anovulation (WHO group II).
  • Wyeth-Ayerst Co. Protocol # 0915A3-300-USA
    Double-blinded, randomised and historical-controlled study, of the safety and efficacy of Premarin/Trimegestone for postmenopausal hormone replacement therapy.
  • Wyeth-Ayerst Co. Protocol # 713B-309-US
    Prospective, double-blinded, randomised study of the safety and efficacy of lower doses of Premarin and Medroxyprogesterone acetate in Postmenopausal Women.
  • Parke-Davis Co. Protocol # 97071603.
    Urinary excretion of Deoxypyridinoline Crosslinks and N-telopeptides in healthy perimenopausal patients: The effect of low-dose oral contraceptives.

Μέλος Επιστημονικών Οργανώσεων:

  • American College of Obstetricians and Gynecologists
  • American Association of Gynecologic Laparoscopists
  • American Society for Reproductive Medicine
  • European Society for Human Reproduction and Embryology
  • The Johns Hopkins Medical and Surgical Association
  • The Kelly Society of the Johns Hopkins Hospital

Συμμετοχή σε επιστημονικά συνέδρια με παρουσίαση:

  • Lambrou, N., Rosanfekr, D., Vlahos, NP., Phelps, JY. “Accuracy and Intraexaminer Variability of Simulated Cervical Dilatation and Effacement Measurements.” The 47th American College of Obstetricians and Gynecologists (ACOG) Annual Meeting, New Orleans, LA. May 20-24, 1998, (Oral presentation)
  • Vlahos, N.P., Phelps, J.Y., Zacur, H.A., Aleem, F. “Changes in the Fallopian Tube Circulation after Treatment of Ectopic Pregnancy with Methotrexate.” The 14thAnnual Meeting of the European Society for the Human Reproduction and Embryology, (ESHRE) G?teborg, Sweden. June 20-24, 1998, (Oral presentation)
  • Fauzia, M., Phelps, J.Y., Vlahos, N.P., Figueira-Armada, L., Garcia, J.E. “Baseline Follicle Stimulating Hormone: Luteinizing Hormone Ratios are not Predictive of Pregnancy Outcome and Ovarian Response to Controlled Ovarian Hyperstimulation.” The 54th Annual Meeting of the American Society for Reproductive Medicine. San Francisco, CA. October 4-8 1998, (Oral presentation)
  • Phelps, J.Y., Figeira, Armada L., Vlahos, N.P., Zacur, H.A., Garcia, J.E. “Low Mid-Follicular Serum: Luteinizing Hormone Concentrations are associated with Significantly Lower Estradiol Concentrations in Patients Undergoing Controlled Ovarian Hyperstimulation for IVF.” The 37th Annual ACOG Conference. The 20th Annual Armed Forces District Meeting. Kissimmee, FL. October 18-21, 1998, (Oral presentation)
  • Vlahos, N.P., Fauzia, M., Whelan, J., Wallach, E.E., Garcia, J.E. “Correlation of Infertility Etiology to IVF Success Rates.” The 4th International Congress: “The young woman at the rise of the 21st century: Gynecological and Reproductive Issues in Health and Disease.” November 18-21,1998 Athens, Greece. (Oral presentation)
  • Vlahos, N.P., Dragasic, K.G., Whelan, J., Wallach, E.E. “Subsequent Development of Cervical Intraepithelial Pathology in Patients with Atypical Squamous Cells of Undetermined Significance.” The 4th International Congress: “The young woman at the rise of the 21st century: Gynecological and Reproductive Issues in Health and Disease.” November 18-21,1998 Athens, Greece. (Oral presentation)
  • Vlahos, N.P., Bugg, E.M., Shamblott, M.J., Garcia, J.E., Gearhart, H.A., Zacur, H.A. “Localization of the Prolactin Receptor in Luteinized Human Granulosa Cells.” Late breaking news in research and technology, 55th Annual Meeting of The American Society for Reproductive Medicine. September 25-30, 1999: Toronto, Canada. (Oral presentation)
  • Figueira, L., Vlahos, N.P., Phelps, J.Y., Zacur, H.A., Garcia, J.E. “Midfollicular Serum LH Concentrations do not Predict Pregnancy Outcome in Controlled Ovarian Hyperstimulation and IVF.” The 55th Annual Meeting of the American Society for Reproductive Medicine: Toronto, Canada: September 25-30, 1999, (Poster).
  • Vlahos, N.P., Dragisic, K.G., Wallach, E.E., Burroughs, F.H, Fluck, S., Rosenthal, D.L. “Clinical Significance of the Qualification of Atypical Squamous Cells of Undetermined Significance: An Analysis Based on Histologic Diagnoses.” District IV annual meeting of the American College of Obstetricians and Gynecologists. Fajardo, Puerto Rico: October 15-19, 1999, (Oral presentation).
  • Vlahos, N.P, Figueira, L., Wallach, E.E., Zacur H.A., Garcia, J.E. “Factors that Predict the Outcome of a Controlled Ovarian Hyperstimulation Protocol for IVF.” District IV annual meeting of the American College of Obstetricians and Gynecologists. Fajardo, Puerto Rico: October 15-19 1999, (Poster).
  • El-Minawi, A.M., Vlahos, N.P., Garcia, J.E. “Follicular Growth during Clomiphene Citrate Ovarian Stimulation for IUI.” District IV annual meeting of the American College of Obstetricians and Gynecologists; Fajardo, Puerto Rico: October 15-19 1999, (Poster).
  • Trevino N, Hermann J, Wehrum M, Vlahos NP, Robinson R, Phelps JY “Open laparoscopy as an alternative to laparotomy for the ectopic pregnancies in the presence of an extensive hemoperitoneum.” The 18th International Meeting of Laparoendoscopic Surgeons. December 4-7, 1999. New York, NY. (Oral presentation).
  • Vlahos NP, Bugg EM, Shamblott MJ, Phelps JY, Garcia JE, Gearhart JD, Zacur HA “Prolactin receptors and Prolactin receptor Gene expression in Luteinized Hyman granulosa cells.” 47th Annual meeting of the Society for gynecologic Investigation March 22-25 2000, Chicago IL
  • Posada M.N., Vlahos N.P., Whelan J.G, Murphy J.M., Zacur H.A, Wallach E.E., Garcia J.E. “Four days of leuprolide acetate prevents premature luteinization in flare-up stimulation protocol.” 16th Annual meeting of the European Society for Reproduction and Embryology (ESHRE), June 25-28 2000. Bologna, Italy
  • Bracero N.J., Jurema M.W., Posada M.N., Whelan J.G., Garcia J.E.,. Vlahos N.P. “Triggering ovulation with leuprolide acetate (LA) instead of human chorionic gonadotropin (hCG) after the use of ganirelix for in vitro fertilization-embryo transfer (IVF-ET) does not compromise cycle out-come and may prevent ovarian hyperstimulation syndrome. The 57th Annual Meeting of the American Society for Reproductive Medicine: October 20-25,2001 Orlando, Florida
  • Jurema M.W., Posada M.N., Bracero N.J., Vlahos N.P., Garcia J.E.. “Beneficial use of ganirelix in controlled ovarian hyperstimulation (COH) cycles in older women undergoing in vitro fertilization (IVF).” The 57th Annual Meeting of the American Society for Reproductive Medicine: October 20-25,2001 Orlando, Florida
  • Posada M.N.,. Jurema M.W,. Vlahos N.P,. Bracero N.J, Wallach E.E., Garcia J.E.. “Should women with poor prognostic factors for controlled ovarian hyperstimulation undergo in vitro fertilization (COH-IVF) using ganirelix?” The 57th Annual Meeting of the American Society for Reproductive Medicine: October 20-25,2001 Orlando, Florida
  • Bracero N, Jurema M, Vlahos N, Kolp L, Garcia J. “Polycystic ovarian syndrome (PCOS) patients have a favorable response to ganirelix acetate during controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF)- embryo transfer (ET).” The 58th Annual meeting of the American Society for Reproductive Medicine: October 12-17,2002 Seattle, Washington

Δημοσιεύσεις:

  1. Pedanic, M., Vlahos, N.P., Pennisi, J.A., Moukhtar, M., Aleem, F.A. “Color and Pulsed Doppler Sonography, Gray-scale Imaging, and Serum CA 125 in the Assessment of Adnexal Disease.” Obstet. Gynecol. 1996; 88: 283-288.
  2. Wallach, E.E., Vlahos, N.P. “The Mechanism of Mammalian Ovulation.” Israel J Obstet Gynecol 1998; 9: 127-31
  3. Vlahos, N.P., Matthews, R., Veridiano, N. “Cervical Sarcoma Botryoides: Case Report and Review of the Literature.” J. Reprod Med 1999; 44: 306-308.
  4. Phelps, J.Y., Figeira-Armada, L., Levine, A.S., Vlahos, N.P.., Rosanfekr, D., Zacur, H.A., Garcia, J.E. “Exogenous Luteinizing Hormone (LH) Increases Estradiol Response Patterns in Poor Responders with Low Serum LH Concentrations.” (J Assist Reprod Genet 1999; 7:363-8).
  5. Whelan III, J., Vlahos, N.P. “Review of the Ovarian Hyperstimulation Syndrome.” Fertil Steril. 2000;73(5);883-96
  6. Phelps, J.Y., Bugg, E.M., Varma, S., Vlahos, N.P., Shamblott, M.J., Gearhart, J.D., Zacur, H.A. “Prolactin Gene Expression in Human Ovarian Follicular Cells.” (Accepted for publication Fertility and Sterility).
  7. Vlahos, N.P., Dragisic, K.G., Wallach, E.E., Burroughs, F.H., Fluck, S., Rosenthal, D.L. “Clinical Significance of Atypical Squamous Cells of Undetermined Significance: An Analysis Based on Histologic Diagnosis.” Am J.Obstet Gynecol. 2000; 182 (4):885-90
  8. Vlahos, N.P., Bugg, E.M., Shamblott, M.J., Phelps, J.Y. Garcia, J.E., Gearhart, J.D., Zacur, H.A. “Prolactin receptor gene expression and immunolocalization of the prolactin receptor and in luteinized human granulosa cells.” Mol. Hum. Reprod.2001;7 (10):1033-1038
  9. Vlahos, N.P., Garcia, J.E. “New Developments in Gonadotropin Therapy.” Postgraduate Obstetrics and Gynecology.1997; 17: 24.
  10. Vlahos, N.P., Phelps, J.Y., Wallach, E.E. “Chronic Pelvic Pain.” Postgraduate Obstetrics and Gynecology 1998; 18:15.
  11. Phelps, J.Y., Vlahos, N.P., Zacur, H.A. “Diagnosis and Contemporary Management of Infertility.” Postgraduate Obstetrics and Gynecology 1998; 18:13.
  12. Vlahos, N.P., Sewell, C., Phelps, J.Y. “Gonadotropin Releasing Hormone Analogs (Agonists and Antagonists).” Contemporary Obstetrics and Gynecology 1998; 43:83-93 (Cover-page article assigned for CME credits).
    Wang, E.W., Vlahos, N.P. “Selective Estrogen Receptor Modulators: Raloxifene.” Postgraduate Obstetrics and Gynecology 1999; 19:10.
  13. Vlahos, N.P., Zacur, H.A. “Hyperprolactinemia.” Resolve 1998; 23:4,1-7.
  14. Vlahos, N.P., Zacur, H.A. “Menopause: An Overview.” Resolve 1998
  15. Vlahos, N.P., Zacur, H.A. “The Laboratory Approach to the Evaluation of Hirsutism.” The Hopkins Medical Letter.
  16. Vlahos, N.P., Zacur, H.A. “Breastfeeding, Prolactin and Ovulation during the Puerperium.” The Endocrinologist, 1999; 451-456.
  17. Friedman YG, Vlahos NP. “Gonadotropin-Releasing Hormone Antagonists: A new therapeutic modality.” Postgraduate Obstetrics and Gynecology 1999; 19:26.
  18. Parish Parker A, Vlahos NP. “Progesterone and Progestins: Physiologic role, preparations, and indications for therapy.” Postgraduate Obstetrics and Gynecology 1999; 20:6
  19. Wolfberg AJ, Vlahos N.P. “Transdermal estrogen replacement therapy” Postgraduate Obstetrics and Gynecology 2000;12:6.
  20. Jurema MW, Vlahos NP, Wallach EE. “Reproductive Health and Cystic Fibrosis” Postgraduate Obstetrics and Gynecology 2001; 21:2
  21. Phelps, J.Y., Bugg, E.M., Shamblott, M.J., Vlahos, N.P., Whelan III J., Zacur, H.A. “Prolactin Gene Expression in Human Ovarian Follicular Cells.” Fertil Steril 2003;79:182-9.
  22. Jurema M, Vlahos NP., ” Un unusual complication of tubal reanastomosis” Fertil Steril 2003;79:624-627

Κεφάλαια Eπιστημονικών Συγγραμμάτων:

  • Vlahos N.P, Gearhart J.D. “Embryology of the female genital tract.” W.H. Hurt. Urogynecologic Surgery, 2nd Ed.Philadelphia: Lippincott, Williams and Wilkins.
  • Whellan J.D., Vlahos N.P., Wallach E.E. “Contemporary management of Leiomyomata” In “Contemporary therapy in Obstetrics and Gynecology Issues and Controversies 2000/2001″(In press )
  • Bankowski B, Vlahos NP . ” Infertility and Assisted Reproductive Technologies” The Johns Hopkins manual of Gynecology and Obstetrics (2nd edition)
  • Boykin DC, Vlahos NP. “Repeated Pregnancy loss” The Johns Hopkins manual of Gynecology and Obstetrics (2nd edition)
  • )Chou B, Vlahos NP. “Abnormal Uterine Bleeding” The Johns Hopkins manual of Gynecology and Obstetrics (2nd edition)